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Hydrochlorothiazide 
DescriptionHydrochlorothiazide sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug that acts by inhibiting the kidney's ability to retain water. This reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance.
Hydrochlorothiazide Reviewbrand names: Ezide, Esidrix, HydroDIURIL, Oretic, Microzidegeneric names: Hydrochlorothiazide, hydrochlorothiazide, Hydrochlorothiazide Capsules,, Amiloride hydrochloride How does it work?Carace plus tablets contain two active ingredients, lisinopril and hydrochlorothiazide. Lisinopril is a type of medicine called an ACE inhibitor. Hydrochlorothiazide is a type of medicine called a thiazide diuretic. These are both medicines used to lower high blood pressure.ACE inhibitors such as lisinopril work by blocking the action of a compound in the body called angiotensin converting enzyme (ACE). Normally ACE produces another compound called angiotensin II, as part of the body's natural control of blood pressure. Angiotensin II causes blood vessels to constrict and narrow, which increases the pressure within the blood vessels. As lisinopril blocks the action of ACE, it reduces the production of angiotensin II. This means that the blood vessels are allowed to relax and widen. The overall effect of this is a drop in blood pressure, hence lisinopril can be used to lower high blood pressure. Diuretics such as hydrochlorothiazide are sometimes referred to as ‘water tablets’. They remove excess fluid from the body by increasing the production of urine. Diuretics act in the kidneys. They work by causing the kidneys to increase the amount of salts, such as potassium and sodium, that are filtered out of the blood and into the urine. When these salts are filtered out of the blood by the kidneys, they draw water alongside them. As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood and into the urine. Removing water from the blood decreases the volume of fluid circulating through the blood vessels. This subsequently decreases the pressure within the blood vessels. Diuretics can therefore be used to lower high blood pressure. The combination of lisinopril with hydrochlorothiazide is used when blood pressure has not been lowered sufficiently using lisinopril on its own. What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions: •diabetes •gout •kidney disease, sulfa drugs, other medicines, foods, dyes, or difficulty passing urine •liver disease •pancreatitis •systemic lupus erythematosus (SLE) •an unusual or allergic reaction to hydrochlorothiazide, small amounts of urine Possible food and drug interactions when taking HydrochlorothiazideHydroDIURIL may increase the effects of alcohol. Do not drink alcohol while taking Hydrochlorothiazide. If HydroDIURIL is taken with certain other drugs, decreased, the effects of either could be increased, or altered. It is especially important to check with your doctor before combining HydroDIURIL with the following: What is it used for?
Where can I keep my medicine?Keep out of the reach of children in a container that small children cannot open. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Special information if you are pregnant or breastfeedingThe effects of HydroDIURIL during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. HydroDIURIL appears in breast milk and could affect a nursing infant. If Hydrochlorothiazide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished. |
